A Proven Difference
MiddleBrook™ was founded on the premise that the efficiency and efficacy of antibiotics, and anti-infectives in general, may be improved by front-loaded dosing in rapid, sequential pulses.
Our preliminary findings in both laboratory and animal studies support this premise. They indicate that the pulsatile dosing of certain antibiotics not only eliminates more bacteria and may reduce the emergence of antibiotic-resistant bacteria strains, but that it is able to do so at significantly lower drug concentrations and with potentially shorter courses of therapy than those required under currently available treatments.
For example, our preclinical studies have shown the following:
- Amoxicillin can be enhanced to kill more intermediate-resistant Strep. pneumoniae by PULSYS™ than with the current two or three times a day dosing. (Cha R and Rybak MJ (2004). Journal of Antimicrobial Chemotherapy, 54:1067-1071)
- Antibacterial action for amoxicillin can be demonstrated for Strep. pneumoniae when dosed by PULSYS even at drug concentrations that are not expected to inhibit growth, let alone produce killing. (Cha R and Rybak MJ (2004) Journal of Antimicrobial Chemotherapy, 54:1067-1071)
- When dosed by PULSYS at concentrations otherwise expected to be ineffective, clarithromycin kills resistant Strep. pneumoniae more effectively than when dosing two or three times a day. (Leuthner KD, Cheung C, Rybak MJ (2004). 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract A1169)
- The combination of amoxicillin and clarithromycin eradicated resistant Strep. pneumoniae to undetectable levels when dosed by PULSYS, while two and three times a day regimens were ineffective against the organism. (Leuthner KD, Cheung C, Rybak MJ (2004). 44th Interscience Conference on Antimicrobial Agents and Chemotherapy, Abstract A1169)
- Penicillin intermediate-resistant Strep. pneumoniae become resistant after once or twice a day dosing of amoxicillin, but not when dosed by PULSYS. (Isbister J, Rudnic E, Harding R, Treacy D, Chandhoke V, White J (2002). 102nd American Society for Microbiology (ASM) General Meeting, Abstract A112)
